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pentobarbital will lessen the level or outcome of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or outcome of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Phenobarbital lowers the plasma amounts of dicumarol (title F